Three women of our AiPBAND project are working on biosensors for glioma diagnosis. Biosensors are analytical devices used for the detection of a broad spectrum of analytes, as for example chemical substances, pollutants or biomarkers. Various types of biosensors are commonly used: enzyme, optical or electronic-based. In the context of this project and brain cancer diagnostics, applications for all of these types of biosensors for brain cancer biomarker detection are being validated. You can see a specific example here in the form of a personal update from Meenu Selvaraj.
In August, 2019 Mina and Vanessa will attend a PhD Summer School on Micro and Nano Sensors at DTU in Copenhagen, where they will get an overview on state of the art sensors and where they give hands-on experience in sensor fabrication, surface functionalization and sensor applications.
In our March update we told you about Yagmur and Vanessa that work with enzyme-based and optical biosensors for GBM diagnosis. This month, we have an update from Mina, who is working on electronic biosensors.
“The objective of my project is to develop a biosensor for the detection of DNA methylation, which has been shown to be a relevant biomarker for not only glioma but also for some other types of cancer. Throughout this project I will be developing two types of biosensors. One of them is based on an electrochemical technique using commercially available screen printed electrodes. This technique is famous for its simplicity and low cost as well as high selectivity and accuracy. Currently I am doing optimization processes for various fabrication steps and later on I will be testing the selectivity, specificity and reproducibility of the developed biosensor on human serum.”
Mina Safarzadeh, ESR-1, University of Plymouth (UK)